The Indian Institute of Science is in Bengaluru, Karnataka. Its history page says it came into existence on 27 May 1909, backed by Jamsetji Nusserwanji Tata and the Mysore State government, and opened to students in 1911. The original Bangalore site of 371 acres and 16 guntas was provided by the Regent Queen; the institute has since added a 1,500 acre campus at Challakere in Chitradurga district. It has been a deemed to be university under the UGC Act since 1958.

Faculty are organised in seven divisions, from Biological Sciences to Physical and Mathematical Sciences. IISc in Numbers reports 5,678 students on roll, 490 faculty, 363 postdoctoral fellows and 262 administrative staff as of 31 January 2026. In October 2018 IISc signed a memorandum of understanding with the then Ministry of Human Resource Development to operationalise its Institution of Eminence status.